摘要
Objective To determine the effect of coptopril on vascular smooth muscle cells proliferation andneointima formation in arteries after balloon angioplasty in atherosclerotic animal model. Methods Balloonangioplasty was performed in 16 atherosclerotic New Zealand white rabbits. Experimental animals (n=8) receivingcaptopril 12.5mg/(kg· d) /from 7d before to 28d after balloon angioplasty were compared to controls (n=8). Fourweeks after balloon angioplasty, iliac arteries were isolated for flow cytometric assay and morphometric analysis.Results Flow cytometric assay indicated that the numbers of vascular wall cell cycle in S,G2 and M phases weresignificantly less in coptopril - treated group than those in control (P<0.01), but the numbers of vascular wall cellcycle in G0 and G1 phases were more than those in control (P<0.05). Morphometric analysis showed that thethickness of vascular wall was significantly less in captopril- treated group than control animals. Conclusion Our data suggested that in rabbits the vascular proliferation response after balloonangioplasty may be reduced by early treatment with captopril.
Objective To determine the effect of coptopril on vascular smooth muscle cells proliferation andneointima formation in arteries after balloon angioplasty in atherosclerotic animal model. Methods Balloonangioplasty was performed in 16 atherosclerotic New Zealand white rabbits. Experimental animals (n=8) receivingcaptopril 12.5mg/(kg· d) /from 7d before to 28d after balloon angioplasty were compared to controls (n=8). Fourweeks after balloon angioplasty, iliac arteries were isolated for flow cytometric assay and morphometric analysis.Results Flow cytometric assay indicated that the numbers of vascular wall cell cycle in S,G2 and M phases weresignificantly less in coptopril - treated group than those in control (P<0.01), but the numbers of vascular wall cellcycle in G0 and G1 phases were more than those in control (P<0.05). Morphometric analysis showed that thethickness of vascular wall was significantly less in captopril- treated group than control animals. Conclusion Our data suggested that in rabbits the vascular proliferation response after balloonangioplasty may be reduced by early treatment with captopril.
