人参茎叶中二醇组皂甙对小鼠学习记忆及铜、锌、锰含量的影响

Effects of panaxadiol saponins on the learning memory of mice and on the contents of Cu,Zn and Mn in their blood

采用跳台法、火焰原子吸收分光光度计法分别研究了人参茎叶中二醇组皂甙(PDS)对小鼠学习记忆和全血铜(Cu)、锌(Zn)、锰(Mn)微量元素含量的影响. 结果表明,不同给药剂量各实验组小鼠跳台错误次数明显低于对照组(P<0.01),潜伏期明显延长(P<0.01);各实验组全血Cu含量均高于对照组(P<0.01),而Zn含量没有变化(P>0.05),Mn含量随给药剂量增加而增高,提示PDS具有提高小鼠学习记忆作用,可能与Cu、Mn含量增高有关.

The effects of panaxadiol saponins(PDS) on the learning memory of mice and on the contents of Cu, Zn and Mn in their whole blood were studied by step down test and FAAS. The results showed that the mice of the experimental groups made fewer mistakes (P < 0.01) and their step-down latency was longer(P < 0.01) than the mice of the control group. The content of Cu in each experimental group was higher than that in the control group, there was no change in the Zn content and the Mn content increased as the doasage increased. It is suggested that PDS has the effect on improving the learning memory of mice, which may have something to do with the increase of the Cu and Mn contents.