蒲公英水煎液对环磷酰胺诱导的实验性小鼠精子畸形的影响

The Effect of Water Boiled Juice of Taraxacum Mongolicum Hand-Mazz on Sperm Aberration Induced by Cyclophosphamide in Mice

目的 :研究蒲公英水煎液对实验性小鼠生殖细胞遗传物质的影响。方法 :应用小鼠精子畸形实验 ,观察蒲公英水煎液本身能否诱发雄性生殖细胞遗物质的损伤 ;以及对环磷酰胺诱导的雄性生殖遗传物质损伤是否具有抑制作用。结果 :蒲公英水煎液本身不能诱发实验性小鼠精子畸形 ;对环磷酰胺诱导实验性小鼠精子畸形具有明显抑制作用。结论 :蒲公英水煎液具有一定的抗突变作用 ,可安全应于临床肿瘤治疗。

Objective:To analyze the effect of water boiled juice of Taraxacum mongolicum Hand_Mazz(TM) on genetic substances in reproductive cells in male mice.Methods:The mutation rate was indicated with sperm aberration(SA) test. Results:TM did not induce SA in male mice itself,but decreased SA induced by cyclophosphamide(CP) obviously.Conclusion:TM has anti_mutagenesis effect,which could be used safely to treat tumors clinically.