雌激素与α_1-受体阻滞剂联合治疗前列腺增生症研究

A Study on the Effect of Diethylstilbestrol in Combination with Prazosin (an Antagonist of α_1-receptor) on Hyperplasia of Prostate

目的 :探讨雌激素与α1-受体阻滞剂作为低值药物治疗前列腺增生症的应用前景。方法 :自 1998年 8月～ 1999年 6月采用Dreithylstilbestrol_prazosin联合治疗 8所医院 80例BPH病人与数量相同的高值药物对照组 proscar_Hytrin及空白对照组对排尿症状改善比较 ,总结两组药物的疗效。结果 :使用安慰剂 2 0周后的空白对照组病人IPSS评分及MFR无明显改善 ,对照组病人IPSS评分与MFR改善率分别为 6 2 %和 34% ,高值药物对照组对IPSS评分及MFR改善率最佳 ,为 82 %和 53%。结论 :雌激素与α1_受体阻滞剂联合应用治疗BPH仍有较好疗效 ,虽各改善指标改善不及高值药物对照组 ,但价格极低 ,副作用可以接受 ,不失为我国贫困地区及第三世界发展中国家的BPH病人提供一种有效的治疗方案。

Objective: To explore the applicative prospect of diethylstilbestrol and α 1_receptor antagonist as cheap drugs treating hyperplasia prostate. Method: From August 1998 to June 1999,diethylstilbestrol plus prazosin were used to treat 80 cases with hyperplasia prostate in eight hospials,and their effect of improving disuria was compared with the group of expensive drugs-proscar plus hytrin and the group of blank control.Results: Twenty weeks after the administration of placebo the IPSS scores and MFR in blank control did not obviously improve,but in the experiment group the rate of improvememt in IPSS and MFR was 62% and 34%,respestively,and that in the group of expensive drugs was still higher (82% and 53,respectively). Conclusion:combined administration of diethylstilbestrol and α 1_receptor antagonist is quite effective in treating hyperplasia prostate,although slightly less effective than the expensive drugs,they are extremely cheap and with only acceptable side effects. So,they are suitable for hyperplasia prostate patients in some poor areas of our country as well as in some developing countries.