甘油果糖和甘露醇对脑损伤后血流变影响的对比

Comparison Between the Effects of Glycerol Fructose and That of Mannitol on the Hemorheological Properties of Clinical Cases with Head Injury

目的：探讨甘油果糖和甘露醇对颅脑外伤后血液流变学的影响，揭示其对降低颅内高压的作用机理。方法：采用前瞻性临床对照研究，将颅脑外伤患者随机分组为（１）实验组（３０例）和（２）对照组（３０例），分别给予甘油果糖和甘露醇治疗，对两组患者治疗前后的血液流变学指标作比较。结果：实验组在治疗后的血液流变学指标（血沉、红细胞压积、全血比粘度、全血还原比粘度、血浆比粘度、血细胞聚集指数）较对照组好，有显著的统计学差异（Ｐ＜０．０５～Ｐ＜０．０１）。结论：甘油果糖对比甘露醇能更有效地改善脑外伤后的血液流变学状态，对改善微循环、减轻继发性脑水肿和降低颅内压有重要的临床意义。

Objective: To explore the effects of glycerol fructose and mannitol on the hemorheological propertes of patients with head injury, and to study the mechanisms by which they reduce the elevated intracranial pressure of the patients. Methods: In the prospective clinical study, the patients were divided randomly into two groups, treated with glycerol fructose and mannitol respectively,and the changes of hemorheological indexes in the two groups were compared with each other. Results: After the treatments the hemorheological indexes in glycerol fructose group (such as blood sedimentation, hematocrit, blood viscosity, blood reduction viscosity, plasma viscosity, and erythrocyte aggregation index) were lower than that in mannitol group (P < 0.05- P <0.01 ), indicating better hemorheological condition. Conclusion: As compared with mannitol, glycerol fructose may have better therapeutic effects in arresting brain edema, reducing the intracranial pressure and secondary neuronal damage following head injury, by improving the hemorheological condition of patients.