表皮生长因子对肝损伤动物保护作用的初步研究

The Preliminary Study of the Protection Effect of EGF on the Animals with Liver Damage

通过血清酶学检测与肝细胞超微结构形态观察，研究了单独使用表皮生长因子（ＥＧＦ）和联合使用表皮生长因子（ＥＧＦ）－胰高血糖素（Ｇ）－胰岛素（Ｉｎｓ）对Ｄ氨基半乳糖造成的急性肝损伤小鼠的整体保护作用．结果表明，ＥＧＦ在Ｇ－Ｉｎｓ的协同下能显著提高小鼠存活率，减轻小鼠肝损害程度（Ｐ＜０．０５），促进受损肝细胞生活状态的恢复。因而对改善重症肝炎预后可能有一定意义．

The protection effect of EGF on damaged liver was researched by the sero-eazymological assay and observing the ultrastructure of liver. Itshowdd the coordinatical effect of EGF-G-Ins on the damage of damaged liver and improving the mouse survival rate was more effective than the respective effect of EGF, which probed the possiblity of EGF to treat serious hepatitis.