白三烯B_4研究进展

Development of leukotriene B_4 research

白三稀B_4是细胞膜上磷脂经PLA_2,5-LO,LTA_4水解酶一系列酶催化产生的一个小分子物质,机体大多数组织细胞可产生,合成后通过与合成相分离的释放过程排出胞外,白三烯B_4具有复杂的生理功能,尤其在炎症,免疫方面具有重要的调节作用。它的这些作用是由其在膜上不同的受体介导的,白三烯B4与其它细胞因子相互作用,构成一个调节机体功能的网。

Leukotriene B4 is a small metabolite of phospholipid in membrane through PLA2,5-LO, LTA4 hydrolase and other related enzymes. It is been synthesized in almost all kinds of tissue cells, then transported to outside of the cells, which may be separated from its synthesis. LTB4 shows complex bioactivities, especially in inflam-mation, immune system and plays an important role. Its functions are mediated by its different receptors on the membrane. Also, LTB4 interacts with other cytokines, and they form a network regulating functions of the body.