人心肌细胞钾道通研究进展

Progress in study of potassium channels in human cardiomyocytes

钾通道是心肌细胞上一类具有重要功能的离子通道,是Ⅲ类抗心律失常药物作用的靶点。近年来,随着分子生物学技术的引入、钾通道克隆的出现及人心肌细胞成功分离和单通道的研究,对人心肌细胞上钾通道的激活和失活动力学特征,电压门控机制及离子的选择性等电生理学特性和药理学意义有了一个较全面深入的了解。这些对于抗心律失常药物的开发与研究具有重要的理论指导意义。

Potassium channels which are targets of antiarrhythmic drugs (class III) play an important role in cardiomyocyte membrane. Recently, with the application of molecular biology techniques , development of cloned potassium channels, successful isolation of human cardiomyocytes and research of single channel, scientists have learnedmore characteristics of kinetics, electrophysiology and pharmacology of potassium channels. All these help them to develop and study new antiarrhythmic drugs.