急性胰腺炎患者生长抑素治疗后血小板的形态特征

Blood platelet property in patients with acute pancreatitis after somatostatin treatment

目的研究急性水肿型（AEP）和出血坏死型（AHNP）胰腺炎血小板形态特征的变化特点及生长抑素（SS）治疗的影响方法应用血细胞自动分析仪检测血小板计数（Pt）、平均血小板体积（MPV）和血小板分布宽度（PDW）．结果AEP患者血小板形态特性无明显变化，1wk后，MPV和PDW有显著性升高（t＝-2．35，－2．40，P＜0．05）；常规治疗对血小板形态参数无影响；SS治疗后，MPV和PDW明显升高（t＝－3．46，－4．14，P＜0．01）．AHNP患者Pt明显降抵（t＝3．03，P＜0．01），MPV和PDW明显升高（t＝－2．65，－2．63，P＜0．05）．1Wk后Pt明显升高（t＝4．79，P＜0．001），但MPV和PDW无明显降低；常规治疗后，Pt升高，MPV，PDW均降低（t＝－3．67，5．08，3．13，P＜0．05）；SS治疗后Pt明显升高（t＝－3．50，P＜0．01），MPV，PDW无明显变化．结论AEP与AHNP患者血小板形态特性的变化有明显的不同，可反映病情变化．SS治疗对Pt无明显影响，但可增加血小板的活性，对AHNP者有一定的治疗和预防作用．

AIM To study blood platelet property in patients with acute pencreatitis (AP), and the effect of somatostatin (SS, stilamin or octreatide) on it.METHODS Blood platelet parameters were surveyed by automatic instrument of blood cells analyser in AP patients (n=55 ) before and one week after SS treatment.RESULTS No significant change was found in platelet formation in patients with acute edematous pancreatitis (AEP ). Mean platelet volume (MPV) and platelet distribution width (PDW) was increased after ooe week.No significant effec on lIatelet proprty was found after general treatment, but MPV and PDW was significantly increased after SS treatment. Platelet count (Pt) was becreased, but MPV and PDW in acute hemorrhagic and necrotizing pancreatitis (AHNP) was increased. After one week, Pt was significantly increased, but MPV and PDW had no change. MPV and PDW were markly decreased and Pt was increased after general treatment. A significant increase in Pt, but no change in MPV and PDW was found after SS treatment.CONCLUSION AEP patients have significantly different changes of platelet formative property from AHNP, these can indicate the severity of the disease. Pt has no significant change but platelet activity is increased after SS treatment.