阿昔洛韦与IFN序贯抗HBV感染时血清HBVDNA含量变化

The efficacy of sequential treatment with acyclovir-interferon and affectes of quantities of HBVDNA

目的为探讨HBV感染者单用IFN或阿昔洛韦（Acy）联合IFN序贯治疗时，血中HBVDNA水平变化与疗效关系．方法血清HBsAg，HBeAg，抗HBc：和HBVDNA皆阳性HBV感染者33例．IFN组15例，用重组IFNa-1b300万U，im，1次／d×14，1次／2d×36，共 50支；合用组 18例，用 Acy25 mg／（kg·d），iv计×15，接着 IFNa-1b300万 U，用法同 IFN组，IFN治疗20 d时再用 Acy 15 d，方法同前采用信号引物能量转移定量PCR，测定患者治疗前。中、治疗结束时血清HBVDNA水平并判断疗效．结果完全反应老干扰素治疗前血清HBVDNA含量（拷贝／L）范围 5．03×107～4．58×109；部分反应和无反应者范围 5.68×107～2．37×1015．Acy能降低血中HBVDNA含量，Acy联合IFN序贯治疗组完全反应率（72．2％）明显高于单用IFN组（46．6％）．结论先用Acy降低患者血中HBVDNA含量。

AIM To study the efficacy of treatment with single interferon or acyclovir and interferon Sequentially on hepatitis B virus (HBV), and on uantities of serum HBVDNA METHODS 33 petients inboted with HBV, which were all seropositive of HBsAg, HBeAg, anti-HBc and HBVDNA,was divided into interferon therapeutic group (15 patients) and acyclovir-interferon therapeutic group (18 patients). The serum HBVDNA which were gleaned at the begining of using acyclovir or interferon and the end of all treatment, were quantitated by a quantitative PCR assay which is bosed on Anpisensor and esergy transfer assay,while patients of interferon therapeutic group were treated with alb-interferon simply, those of acyclovirinterferon therapeutic group were treated with acyclovir and albinterferon weuentially.RESULTS Acyclovir and interferon sequentially treatment has more efficient (72.2%) than that of interferon simply (46.6% ) does. on quantities of serum HBVDNA, which is significantly lower (copies/ L) 5.03×10, -4.58×109 in long-term responders than that of nonresponders 5.68×107-2.37×1015 at beining of interferon therapy; the quantities of HBVDNA can be depressed by acyclovir therapy.CONCLUSION Long-term respeders will increase because HBVDNA decreases due to acyclovir before interferon.