戊己胶囊治疗慢性萎缩性胃炎临床研究

Clinical study on therapeutic effect of wuji capsule on chronic atrophic gastritis

目的观察中药戊己胶囊对慢性萎缩性胃炎的治疗效果方法慢性萎缩性胃炎患者100例，应用戊己胶囊（柴胡、白术、佛手、蒲公英等9味药组成）进行治疗．其中轻度萎缩性胃炎42例，中度38例，重度20例，伴肠腺化生41例．Ⅰ°不典型增生13例、男63例，女37例.年龄30岁～65岁，平均51岁±8岁，病程6mo～100mo，平均60．0mo±18．5mo．临床表现胃脘病者86例，胃脘胀满72例，纳呆90例，嗳气34例，口苦20例．连用3mo后，对患者的临床症状、胃粘膜的改善情况进行比较分析．结果经戊已胶囊治疗3mo，临床治愈7例，显效48例，有效34例，无效11例，愈显率55．0％，总有效率为89．0％．轻度萎缩性胃炎42例中有33例转为浅表性胃炎，4例恢复正常，5例无变化；中度萎缩性胃炎38例中间例转为轻度萎缩性胃炎，14例转为浅表性胃炎，3例恢复正常，4例无变化；重度萎缩性胃炎20例中10例转为中度萎缩性胃炎，8例转为浅表性胃炎，2例无变化．肠腺化生轻度26例中消失20例，无变化6例；中度8例，转为轻度化生4例，消失1例，3例无变化；重度7例中有2例转为中度，2例转为轻度化生，3例无变化Ⅰ°不典型增生13例中有7例恢复正常，6例无变化结论戊己胶囊对慢性萎缩性胃炎有良好的治疗作用，对气滞型和虚寒型疗效相同．

AIM To study the therapeutic effect of Chinese herus wuji capsule on chronic atrophic gastritis.METHODS One-hundred petients with chronic atrophic gastritis were treated with wuji capsule. Of them, 42(42% ) were mild, 38(38% ) mtherate and 20(20% ) sever atrophic gastritis and 41 (41% ) and 13(13% ) accompanied with intestinal metaplasia (IM) and Ⅰ degree dysplasia (Dys), respectively. Of the 100 patients, 63 were men and 37 were women, aged 30 - 65 years, and the mean age was 51 ±8 years. The clinicaI manifestations were stomach duck pein (86 patients ), fulless of abdomen (72 ),anorexia (90), eructation (34 ), bitterness of the mouth (20). After treatpent for three months the improvement of patients' symptoms, atrophy of gastric mucosa, IM and Dys were analysed.RESULTS After 3 months with Wu ji capsule, 7 Pstients were recovered, 48 very effective, 34 improved, and 11inflecive. The total efficacy was 89% with 4 normality,and 5 no change. Of the 38 patients with moderate atrophic gastritis, 17 became mild atrophic gastritis, 14 superficial gastritis, 3 normality and 4 no changes. Of the 20 severe atrophic gastritis, 10 turned into moderate atrophic gastritis, 8 superficial gastritis and 2 had no changes. of the 26 patients with mild IM, IM disappered in 20, and 6 had no changes. Of the 8 patients with moderate IM, IM disappeared in 1,4 changed into mild IM,and 3 had no changes. Of the 7 patients with sever IM, 2changed into moderate IM, 2 mild IM, and 3 had no changes. Of the 13 Patients with Ⅰdegree Dys, Dys disappeared in 7 and 6 had no chanpes.CONCLUSION Wu ji capsule has better therapeutic efferts on choric atrophic gastritis.