血脂和雌性激素水平与胆囊结石的关系

Relationship between female hormones, blood lipids and cholelithiasis

目的探讨血脂和雌性激素水平与胆囊结石的关系方法选择经B超、手术证实的胆囊结石患者104例（A组）进行血清雌二醇（EZ）、孕酮（P）、总胆固醇（TC）、甘油三酯（TG）测定，并与54例（B组）健康人进行对比分析．结果男性A组E2，P水平明显高于B组（P＜0．05～0．01），女性育龄期E2水平A,B两组相比差异无显著性（P＞0．05），P高于B组（P＜0．01）．绝经期A组E2，P均高于B组（P＜0．01），女性两组E2／P比值A组均显著低于B组（P＜0．01）.而血清TG，TC及TG／TC比值在男女性A组均高于B组（P＜0．01）。结论胆囊结石患者存在雌性激素及脂类代谢紊乱．

AIM To study the relationship between the female hormones, blood lipids and cholelithiasis.METHODS Serum estradiol (E2), progesterone (P),total cholesterol (TC), triglyceride (TG) were tested in 104 patients (group A ) which confirmed to have cholecystolithiasis by B-mode USG and cholecystostomy and the results were compered with that of 54 normal persons (group B).RESULTS Serum E2, and P levels of the men in group A were remarhable higher than those in group B (P<0.05 -0.01). Serum E2 levels of the child-bore period women had not difference between group A and B (P > 0.05 ), but P levels of group A were higher than that of group B, Serum levels of E2 or P of menopause women in group A were all remarkable higher than those of women in group B (P<0.01). The ratio of E2/P of women in group A were remarkable lower than those in group B (P < 0.001).Serum levels of TG,TC and the ratio of TG/ TC in persons of group A (either men or women) were all higher than those in group B (P<0.01).CONCLSION Female hormones and lipid metabolism of cholecystolithiasis petients are disordered.