同时持续输注化疗合并放疗治疗食管癌125例

Concomitant continous infusion chemotherapy combined radiotherapy for carcinoma of esophagus

目的观察同时静脉输注化疗在食管癌放疗中的增敏、增效作用。方法从1992年3月到1995年10月，我们共收治食管癌患者125例，随机分为两组，其中60例同时持续输注化疗合并放疗（观察组），65例单纯放疗（对照组），两组放疗剂量相同为50—65GY／5—6周。结果观察组在治疗结束时有效率（CR＋PR）为85．0％，对照组为72．3％，两组比较有显著性差异（P＜0．05）；2、3年生存率分别为观察组48．3％和28．3％，对照组36．9％和15．4％，有显著差异（P＜O．05）。结论同时持续输注化疗合并放疗可以提高食管癌放疗的疗效，对放疗有增敏、增效作用，从而延长食管瘤患者的生存时间。

Objective: To evaluate the radiosensitizing effect concomitant continous infusionchemotheropy (CCIC) in patients with esophageal carcinoma. Methods: From March 1992 to Octo-ber 1995, 125 case patients were treated. 60 case were treated with CCIC followed by radiotherapy(study group)and 65 case with radiothrapy alone (control group). These two groups were similar inradiotherapy to deliver 50-- 60Gy/5--6weeks to the primary tumor. Results: It was shown that theoverall response rate of the study group was higher than in the control group (85. 0%, 72. 3%,P<0. 05). The 2 and 3 year survival rates were 48. 3 %, 28. 3% in the study group and 36. 9 %, 15. 4% inthe control group (P＜O. 05),respectively. Conclusion: These results showed that concomitant conti-nous infusion chemotherapy combined radiotherapy was favorable in raising the treatment effect andsurvival rate.