肝硬化大鼠门静脉分支结扎加Ⅱ期肝叶切除

TWOSTAGE HEPATECTOMY WITH PORTAL VEIN BRANCH LIGATION IN CIRRHOTIC RATS

的：观察肝硬变大鼠在门静脉分支结扎后肝脏的改变及术前进行门静脉分支结扎能否提高硬化肝脏对肝大部分切除术的耐受力。方法：用四氯化碳（ＣＣｌ４）诱发大鼠肝硬变模型，进行选择性门静脉分支结扎加Ⅱ期相应肝叶切除，观察硬变的肝脏在门静脉分支结扎后的改变以及Ⅱ期肝叶切除后残肝的再生动态变化。结果：大多数四氯化碳诱发的中轻度肝硬变大鼠可以耐受７０％的门静脉分支结扎，结扎后２周，结扎侧的肝叶出现萎缩，而非结扎侧的肝叶出现代偿性增生肥大；肝大部分切除术前进行门静脉分支结扎可以避免术后残肝门静脉压力的突然升高。

Objective: To investigate the changes of cirrhotic liver after portal vein branch ligation and the rationale of preoperative portal vein branch ligation in improving the tolerability of cirrhotic liver subjected to major liver resection. Methods: Cirrhotic rats induced by carbon tetrachloride were subjected to twostage hepatectomy with preoperative portal vein branch ligation. Results: Most of the light and moderate cirrhotic rats could tolerate 70% portal vein branch ligation, but there was atrophy in the ligated lobes two weeks after the operation, and compensatory hypertrophy in nonligated area. Preoperative portal vein branch ligation can avoid drastic going up of the pressure from portal vein after an extensive hepatectomy. Conclusion: Preoperative portal vein branch ligation plays a role in improving the tolerability of cirrhotic liver subjected to major liver resection.