镇眩饮对椎动脉缺血及正常大鼠脑血流量的影响

Observation of the Effects of Zhenxuanyin(镇眩饮)on Cerebral Blood Flow in Rats with Vertebroarterial Ischemia and Healthy Rats

目的:探讨镇眩饮对大鼠椎动脉缺血的治疗作用;对大鼠4VO 脑缺血的预防作用及对正常脑的影响。方法:采用电凝双侧椎动脉(椎2VO)模型及 Pulsinelli 4VO 模型。用^(123)I-IMP 示踪脑血流。结果:椎2VO 模型除大脑皮质外的脑各部位及全脑血流量下降(P<0.05)。镇眩饮0.3g/kg 可使其恢复正常(P<0.05～0.01)。镇眩饮日剂量0.3g/kg 和1g/kg,连续1周,未观察到有效预防作用。正常大鼠用镇眩饮日剂量0.3g/kg,24h 及1周后,均对全脑血流量无明显影响。结论:椎2VO 是更接近于临床椎-基底动脉缺血性眩晕的模型,镇眩饮对其的治疗效果与对 PuIsinelli 4VO 模型相同。镇眩饮是比较理想的脑血流改善剂,不会引起脑内“窃血”现象。

Objective:To observe the improvement effects of Zhenxuanyin(ZXY)to the rats with vertebra artery infarction, the prevention effect to the Pulsinelli's 4-vessel occlusion(4VO)rats model and the influences to the normal rats brain. Methods:The infarction of the rats' vertebral artery (vertebral 2VO) and the 4 VO rats model were achieved through electrocoagulation.^(123)I-IMP was used to trace cerebral blood flow (CBF).Results:Except that of cerebral cortex,the blood flow of each region was observed to decrease.ZXY when used at 0.3 g/kg was able to normalize the decreased blood flow in cerebral regions.Healthy rats were medicated a daily 0.3 g/kg and lg/kg dosage of ZXY.At the end of a week, they were made into 4 VO model rats.No prevention effect was found.ZXY has no obvious effect on the CBF of normal rats.Conclusion:ZXY could normalize the decreased CBF of rats with vertibroarterial ischemia,but has no obvious effect on the CBF of normal rat.ZXY is an ideal CBF improving agent.