中药复方对大鼠脑血流量的影响

Study on Effect of A Traditional Chinese Recipe on Cerebral Blood Flow

目的:探讨具有益肾补气、活血化瘀作用中药复方对脑血流量的影响及其作用机制,为进一步临床应用提供依据。方法:中药复方由人参、当归、三七、水蛭、红花、黄芪、川芎、丹参、淫羊藿、枸杞子、熟地、山茱萸、益智仁、何首乌组成。给正常纯种 SD 大鼠灌饲中药每天1次,共3天,然后测定脑血流量变化。结果:不同剂量的中药均能增加大鼠脑血流量,与对照组比较差异显著(P<0.05)。结论:实验用中药能增加 SD 大鼠脑血流量,这一作用与方中多种活血化瘀药物有关。

Objective:To explore the effect and mechanism of a traditional Chinese medicine recipe(TCM)for tonifying Kidney, invigorating Qi and activating blood circulation to remove stasis on cerebral blood flow in order to provide an experimental basis for clinical application of the recipe.Methods:Healthy pure bred SD rats were given by the TCM recipe for 3 days, and the changes of cerebral blood flow were observed.Results:Different doses of the recipe could increase the cerebral blood flow of rats,and significant difference was found as compared with the control group(P<0.05).Conclusion:The recipe could increase cerebral blood flow,this effect may be related with the effect of activating blood circulation to remove stasis.