摘要
目的:观察黄丹冲剂对模型大鼠糖化血红蛋白(HBA_1c)及肾小球基底膜变化的影响。方法:采用链脲菌素(30mg/kg)处理 SD 大鼠,并加喂高热量食物,建立类似Ⅱ型糖尿病的肥胖糖尿病大鼠模型,给模型鼠灌服黄丹冲剂,观察其降 HBA_1c 及对肾小球基底膜的保护作用。结果:黄丹冲剂虽无降血糖作用,却有明显降低 HBA_1c 及减轻或延缓肾小球基底膜增厚的作用。结论:该方能降低 HBA_1c 及减轻或延缓肾小球基底膜增厚。
Objective:To observe the effect of Huangdan granule(HDG)on the value of hemoglobin A_(1c)(HBA_(1c))and the changes of glomerular basement membrane in experimental model rats.Methods:Obese diabetic rat models similar to dia- betes type 2 was established through treating with streptozotocin(STZ,30mg/kg),and feeding with high fat and carbo- hydrate diet.Then HDG was given orally to 40 model rats.Resnlts:HDG could not decrease the value of blood sugar, but could decrease the value of HBA_(1c)and abate or delay the paehynsis of glomerular basement membrane.Conclusion: HDG could decrease HBA1c and abate or delay the pachynsis of glomerular basement membrane.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1998年第S1期114-116,371,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
黄丹冲剂
链脲菌素
肾小球基底膜
糖化血红蛋白
Huangdan granule
streptozotocin
glomerular basement membrane
hemoglobin A_(1c)
