摘要
目的:探讨小柴胡汤对鼠肝纤维化的抑制作用及该抑制作用与活性伊东细胞间的相互关系。方法:分别腹腔注射二甲基亚硝基胺和猪血清复制两种肝纤维化动物模型并投予小柴胡汤观察其预防与治疗作用。结果:小柴胡汤可促进肝维生素 A 含量恢复;降低肝胶原含量和明显抑制肝前α-Ⅰ型胶原的基因表达;显著减少Ⅰ、Ⅲ型胶原在肝脏沉积,明显减少。α-平滑肌原纤维阳性的伊东细胞的数目。结论:小柴胡汤可防治鼠肝纤维化的发生与发展。
Objective:To observe the effect of Xiaochaihu decoction (XCHD) on hepatic fibrosis in rats and the relationship be- tween the role with the active Ito calls.Methods:The hepatic fibrosis models induced by a single injection of dimethylni- trosamine(DMN) and pig semm(PS) respectivdy were used to observe the preventive and therapeutic effects of XCHD. Results:XCHD could elevate the retinol palmitate (RP) contents,reduce hepatic collagen contents and inhibit obviously gene expression of hepatic pro-alphal I collagen,decreased evidently the deposition of type Ⅰ and Ⅲ collagen,and dropped the numbers of alpha smooth muscle action (α-SMA) positive ho cells in the liver of rats.Conclusion:XCHD could prevent and treat the occurrence and development of hepatic fibrosis in rats.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1998年第S1期171-174,380,共5页
Chinese Journal of Integrated Traditional and Western Medicine
