复方茵陈蒿汤对兔奥狄氏括约肌肌电活动及胆总管压力的影响

The Influence of Compound Yinchenhao Decoction(茵陈蒿汤)on Myoelectric Activity of Oddi's Sphincter and Biliary Pressure in Rabbits

目的:揭示奥狄氏括约肌肌电活动与机械收缩的关系和复方茵陈蒿汤治疗胆石症的作用机制。方法:采用同步记录技术,动态观察灌胃前后兔奥狄氏括约肌肌电活动及胆总管压力的变化。结果:胆总管压力波动与括约肌肌电发放在时程上一致,药后30～75min,括约肌肌电脉冲频数明显增加,其增值明显高于相应时间的给予等量水灌胃的对照组(P<0.05,60min,P<0.01),胆总管压力无相应的升高。结论:奥狄氏括约肌肌电活动与机械收缩相藕联,复方茵陈蒿汤通过兴奋括约肌肌电活动,增强括约肌的节律性舒缩,促进胆汁排放。

Objective:To reveal the relationship between the myoelectric activity and the mechanical contraction of Oddi's sphincter and to study the mechanism of the curative effect of compound Yinchenhao decoction(YCHD) on cholelithiasis. Methods:The changes found in electromyogram (EMG) of Oddi's sphincter and biliary pressure of rabbits before and af- ter the administration of the decoction were recorded with synchronous recording technique,then the changes were anal- ysed.Results:The fluctuation of biliary pressure correlated with electric discharges of Oddi's sphincter,and the electric discharges increased obviously during 30-75 minutes after the administration of the YCHD.There was significant differ- ence between the changes of YCFID group and the control group,which were given water equal to the decoction in volume (P<0.05;60 min;P<0.01),but the biliary pressure did not increase correspondingly.Conclusion:Compound YCHD could promote biliation by exciting myoelectric activity and enhancing rhythmic contraction of Oddi's sphincter.