克癌胶囊对肝癌组织的病理形态学影响

An Observation on the Effect of Pathologic Changes of the Hepatoma with Ke'ai Capsule(克癌胶囊)

目的:揭示克癌胶囊抗肝癌的病理学基础。方法:通过肉眼大体、光镜、电镜观察。结果:与对照组相比,克癌胶囊组绝大多数癌组织有明显完整的包膜,癌细胞浸润至周边组织中很少。光镜下见瘤灶周围常形成较完整的反应带,反应带中有大量淋巴细胞、巨噬细胞等;淋巴细胞很大一部分属于 T 细胞。电镜下癌细胞内细胞器如线粒体等显著扩张、脂褐素明显增多,核浓缩、染色质积聚、断裂、贴向核膜,出现走向凋亡的特征。结论:说明其抗癌作用包括直接作用于癌细胞和间接增强宿主细胞免疫系统两个方面。

Objective:To study the pathologic changes of the hepatorna (HepA) with Ke' ai capsule( KAC,an anti-tumor drug).Methods:With macropathology,optical microscopy and electron microscopy,the comparative effects on the can- eer tissue and cells treated with KAC were observed.Results:A lot of cancer tissues had the marked and intact capsules in KAC group,only a few cancer ceils infiltrated into the periphery tissues of the carcinoma focus as well.In KAC group, optical microscope showed that around the HepA focus there were many inflammatory cells infiltrated,which formated a marked and perfect reaction zone that included lots of T cells and macrophagocytes.By electron microscope investigation, there were lots of expanded cell organs,such as mitoehondria,increased lipofuscin and concentrated broken chromosome near to the nuclear membrane in HepA cells,which further suggested the cellular apoptosis was induced.Conclusion: KAC might affect the cancer cells directly and enhance cytoimmunity of the host,which could kill or inhibit the cancer cells.