便通胶囊健脾固本作用的研究

Study on Effect of Biantong Capsule(便通胶囊)in Strengthening Spleen and Body Resistance

目的:通过对便通胶囊健脾固本的药效学研究,揭示其疗效特点的内在机制。方法:将小鼠分成不同剂量的便通胶囊组、空白对照组(生理盐水)和阳性对照组(黄芪或麻仁丸),观察便通胶囊对小鼠淋巴细胞转化率、溶血素抗体水平、NK 细胞活性及胸腺指数的影响;对耐乏氧和耐疲劳的影响;对不同肠段水分含量的影响。结果:便通胶囊能提高小鼠淋巴细胞转化率、促进溶血素抗体的形成,增强 NK 细胞活性,提高胸腺指标,提高小鼠耐乏氧和耐疲劳能力,对小肠水分吸收无影响。结论:改善免疫功能,提高体能和适应能力及对小肠段水分吸收的作用特点,构成了便通胶囊健脾固本的主要药效学内涵,而健脾固本保证了本药通而不泻,下不伤正疗效特点实现。

Objective:To reveal the therapeutic mechanism of Biantong capsule (BC) in strengthening Spleen.Methods:Differ- ent groups of Mice were administrated with BC (BC group),normal saline (negative control group) and Radix Astragali or Maren pill (麻仁丸,positive control group),respectively.And the lymphocyte transformation rate,hemolysin anti- body level,natural killer (NK) cell activity,thymns index,anti-anoxia ability and endurance,water content in large and small intestines of animals were observed.Results:BC could raise lymphocyte transformation rate,enhance hemolysin an- tibody formation,promote NK cell activity,elevate the thymus index,strengthen ability of anti-anoxia and endurance, and no influence was observed on water absorption of small intestine.Conclusion:The pharmacologic characteristics of BC,i.e.immune function improving,body ability and adaptivity elevating and effect on water absorption of small intes- tine,constitute its main pharmacologic effect in strengthening Spleen and body resistance,which bring about the distinc- tive therapeutic effect of BC not in purging but in relieving without impairment of vital energy.