摘要
目的明确nm23-H_1基因在垂体腺瘤中的表达及其临床意义。方法采用免疫组织化学染色（SP）法对62例垂体腺瘤nm23-H_1基因表达进行回顾性研究。结果侵袭型垂体腺瘤nm-H_1基因表达水平显著低于非侵袭型（P＜0.01）;Ⅲ、Ⅳ级垂体腺癌nm23-H_1基因表达水平显著低于Ⅰ、Ⅱ级（P＜0.05）;nm23-H_1基因表达水平下降与垂体腺瘤患者的性别、年龄及肿瘤分泌功能无显著相关性（P＞0.05）。结论nm23-H_1基因可能在会作腺瘤的侵袭过程中起重要作用,其表达改变是反映垂体腺癌侵袭性的敏感指标。
Objective To investigate the expression of nm23-H1gene and its clinical significance in pituitary adenoma. Method Expression of nm23-H1 gene was assessed retrospectively in 62 cases of pituitary adenoma by immunohistochemical staining (streptavidin peroxidase conjugated method, SP). Results The expression of nm23 - H1 gene in invesive pituitary adenoma was lower compared with noninvasive (P＜0. 01 ). A significant difference of nm23 - H1 gene expression was found between, Ⅲ、Ⅳ grades and Ⅰ、Ⅱ grades (P＜0. 05). The decreased expression of nm23 -H1 gene had no remarkable correlation with sex,age and founctional status of the tumor (P＞ 0.05 ). Conclusion nm23-H1 gene may play an important role in the invasive prosess of pitaitary adenoma and it is a sensitive indicator for invasiveness in pituitary adenoma.
出处
《中国肿瘤临床与康复》
1998年第6期5-7,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
