胰腺癌中TGFβⅠ和TGFβⅡ受体研究

Research of TGFβⅠ and TGFβⅡ Receptors in pancreatic cancer

目的通过对TGFTGFβⅠ和TGFβⅡ受体的基因表达分析,了解两种受体的基因表达与胰腺癌的相关性。方法对12例正常胰腺组织和35例胰腺癌标本进行ABC免疫组织化学染色分析,结果以P＜0.05有意义。结果TGFβⅠ和TGFβⅡ受体的阳性率分别为68.6％（24／35）和60％（21／35）两者均阳性为51.4（18／35）;并发现两种受体的基因表达与胰腺癌的分期有关（P＜0.01）,而TGFβⅡ受体与胰腺癌的分化程度有关（P＜0.05）。结论结果提示两种受体的表达与胰腺癌的发生有关,且对此癌的诊断有意义。

Purpose By analysis of TGFβⅠ apd TGFβⅡ receptors, the relationship of two receptors was investigated in pancreatic cancer. Methods Twelve normal pancreas and 35 patients with pancreatic cancer were collected and analyzed by the ABC immunohistochemistry. Less than 0. 05 was significantly considered. Results The positive rates of TGFβⅠ and TGFβⅡ receptors were 68. 6(24/35) and 60% (21/35) respectively,both 51. 4 % (18/35) ; The expressive correlation between TGFβⅠ and TGFβⅠⅡ receptor genes,phase in pancreatic cancer was found (P<0. 01 ), but TGFβⅡ receptor has relationshiop with differentiation (P<0. 05). Conclusion The results suggest that expression of two receptors has relationship with pancreatic cancer and there is singnificance in diagnosis of pancreatic cancer.