齐墩果酸对大鼠血糖的影响

The Effects of Oleanolic Acid on Serum Glucose Levels of Rats

目的:研究齐墩果酸对高血糖大鼠的降血糖作用。方法:(1)正常血糖大鼠试验:齐墩果酸按40mg·kg^(-1)、80mg·kg^(-1)和120mg·kg^(-1)3个剂量组,灌胃给药,2次/d,连续15d。(2)高血糖大鼠试验;也按以上方法分为3个剂量组,灌胃给药,2次/d,连续15d。实验结果用t检验。结果:(1)正常血糖大鼠实验:齐墩果酸对正常血糖大鼠血糖无明显影响。(2)高血糖大鼠试验:齐墩果酸低剂量(40mg·kg^(-1))组,给药前后血糖平均值分别为21.64±3.26mmol/L和14.18±3.06mmol/L;齐墩果酸中剂量(80mg·kg^(-1))组,给药前后血糖平均值分别为24.67±2.17mmol/L和18.64±1.82mmol/L;齐墩果酸高剂量(120mg·kg^(-1))组,给药前后血糖平均值分别为27.58±4.12mmol/L和11.74±4.30mmol/L。结果显示,齐墩果酸能明显降低高血糖大鼠的血糖(P<0.05),且与剂量相关。结论:齐墩果酸对正常血糖大鼠的血糖无明显影响,对高血糖大鼠有显著的降血糖作用。

Objective: to examined the actions of Olean - olic acid on blood sugar of healthy rats, hyperglycemic rats caused by tetraoxyprimidine or senium. Method: (1) healthy rats, P. O. Oleanolic acid (40mg · kg-1, 80mg · kg-1, 120mg · kg-1), 2 times/d, 15 days. (2) hyperglycemic rats, P. O. Oleanolic acid, the does same to before. Results: ( 1 ) oleanolic acid showed no Significant effects on serum glucose levels in normal rats. (2) The blood sugarcontents of the hyperglycemic rats the low, mediu and high does groups before administration were individually: 21. 64±3. 26mmol/ L、 24. 67 ± 2. 17mmol/L and 27. 58 ± 4. 12mmol/L and after administration were individually: 14. 18 ± 3. 06mmol/L, 18. 60±1. 82mmol/L and 11. 74±4. 30mmol/L. The blood sugar levels of hyperglycemic rats were decreased by P. O. Oleanolic acid (P<0. 05) and in a dose -dependent manner. Conclusion: Oleanolic acid showed no significant effects on serum glucose levels of normal rats. The blood sugar of the hyperglycemic rats were decreaseased by Oleanolic acid.