急性脑梗死患者血清LPO、SOD和GSH-Px含量的改变和临床意义

Changes of LPO,SOD and GSH Px Concentration in Serum of Cerebral Infarction Patients and Their Significance

探讨脑梗死患者体内自由基含量的改变及其与脑缺血损伤的关系，为临床治疗提供一定的理论依据。我们对２７例急性脑梗死患者血清ＬＰＯ、ＳＯＤ和ＧＳＨ－Ｐｘ进行测定，并与对照组进行比较，结果显示病人组ＬＰＯ含量和ＬＰＯ／ＳＯＤ比值明显高于对照组，ＳＯＤ含量明显低于对照组，ＧＳＨ－Ｐｘ含量和ＬＰＯ／ＧＳＨ比值与对照组无显著差异，提示自由基反应参与脑缺血损伤过程。

This study was to discuss the changes of free radical in cerebral infarction patients and the relationship between free radical and cerebral injury and to afford theoretical basis for clinical treatment.We assayed LPO,SOD and GSH Px concentration in serum of 27 patients with cerebral infarction.The result showed that the concentration of LPO and LPO/SOD ratio in serum of patient group were significantly higher than that of control group and SOD was lower.The concentration of GSH Px and LPO/GSH Px ratio in serum had no significant difference compared with control group.Our results support that the free radical reaction may take part in the developing of cerebral ischemia injury.