血小板α-颗粒膜蛋白测定与糖尿病微血管病变关系的研究

A Atudy on Relations Between Platelet α-Granule Membrane Qycoprotein Measurement and Microangiopathy Inpatients with Diabetes Mellitus

目的:研究血小板功能与Ⅱ型糖尿病微血管病变两者间的关系,方法:用放射免疫分析法测定的46例Ⅱ型糖尿病患者(有微血管病变20例,无微血管病变26例)和10例健康对照者的血浆CNP-14O浓度和外周血小板计数结果:Ⅱ型糖尿病患者血浆CMP-140浓度较对照组明显增高(P<0.05)有微血管病变组较无微血管病变组明显增高(P<0.001) 糖尿病组与对照组血小板计数无差异(P>0.05)GMP-140水平变化与空腹血糖、血浆胆固醇、年龄无相关性,与病程呈正相关,(r=0.407,P<0.01)。

Object: Study on relations between platelet function and MDDM mioroangiopathy. Methods: The consistency of GMP- 140 in plasma in 46 cases with MDDM (20 with and 26 without nucroangiopathy)and 10 controls were assayed by radioinummunoassay and also simultaneously with direct platelet count. Results:The consistency of CMP- 140 in plasma in N1DDM was remarkably higher than in controls(P< 0.05). the consistency of GMP- 140 was remarkably higher ( P < 0.001) .in cases with microangiopathy than without microanpiopa-thy.No differences existed in platelet count between MDDM in pliisnia and disease period( r = 0.470; P < 0.01). No correlation was found the consistency of GMP - 140 was remarkably higher ( P < 0.001) . in cases with microangiopathy than without microangiopathy . No differences existed in platelet count between NIDDM in plasma and disease period( r = 0.407;P < 0.01 ). No correlation was found the consistency of GMP - 140 in plasma and blond glucose and cholesterol and age. Conclusion: Mioroangiupatliy in NIDDM had close relation with platelet function and the consistency of GMP- 140 in plasma.