两种新的β-二戊基环糊精作气相色谱固定相的研究(英文)

Investigation on Two Novel Substituted β-Cyclodextrins Used as GC Stationary

目的研究了两种二戊基β－环糊精固定相的色谱性能．方法 合成了两种新的七-[2，6-二-O-戊基-3-O-（4-硝基苄基）]-β-环糊精；七-[2，6-二-O-月桂基-3-O-（5-己烯基）]-β-环糊精，并把它们涂渍在弹性石英毛细管柱上，对它们的色谱性能做了表征．结果发现在β-CD的3-O-位上取代基的大小、芳香性等对色谱性能和分离能力有很的影响．在此位置上引入芳香基团和乙烯基，使主-客体分子之间的π-π作用力增强，从而提高了分离芳香族化合物的能力．结论这些新的β-CD衍生物非常适合于用作气相色谱固定相．

Aim To study the chromatographic behaviors of two dipentyl cyclodextrin derivative stationary phases. Methods Two new β-cyclodextrin derivatives, heptakis-[2, 6-di-O-pentyl-3-O-(4-nitrobenzyl)] -β-CD and heptakis-[2, 6-di-O-pentyl-3 -O-(5 -hexenyl)]-β-CD, were synthesized and coatal on fed-silica capillary columns. The chromatographic behaviors of the columns were characterized . Results It was found that the she, polarity, and aromatic property of the substituted group at the 3-position of heptakis-(2, 6 - di - O - pentyl) - β - cyclodextrins greatly influenced their chromatographic properties and separation ability. The introduction of aromatic group or a group containing a double-bond may bring π-π interactions between the host and guest molecules, and therefore increases the separation ability of the β-CDs for substituted benzene isomers. Conclusion The new substituted β-CD compounds are very suitable for being used as gas chromatogaphic stationary phases.