摘要
Oligomer (OMPA) with N(O,Odiisopropyl) phosphoryl arginine (DIPPArg) has been synthesized and its structure has been identified by IR, 1H NMR,31P NMR, and elemental analysis. The functional conversion ratio of this reaction was found to be about 30%. The effect of OMPA on the 5hydroxytryptamine (5HT) receptor was studied by a functional test of constriction in rat blood vessels. The results showed that OMPA inhibited 5HT receptorinduced blood vessels constrictions with pD2 values of 565±021 (OMPA) and 745± 030 (DIPPArg) and exhibited significant pharmacological action of antagonism effect on the 5HT receptor.
Oligomer (OMPA) with N(O,Odiisopropyl) phosphoryl arginine (DIPPArg) has been synthesized and its structure has been identified by IR, 1H NMR,31P NMR, and elemental analysis. The functional conversion ratio of this reaction was found to be about 30%. The effect of OMPA on the 5hydroxytryptamine (5HT) receptor was studied by a functional test of constriction in rat blood vessels. The results showed that OMPA inhibited 5HT receptorinduced blood vessels constrictions with pD2 values of 565±021 (OMPA) and 745± 030 (DIPPArg) and exhibited significant pharmacological action of antagonism effect on the 5HT receptor.
