5-氟尿嘧啶、甲酰四氢叶酸钙和羟基喜树碱联合治疗进展性结直肠癌的初步报告

5-Fluorouracil, Leucovorin and 10-Hydroxyl Camptothecinum in treatment of Advanced Colorectal Cancer

本研究用5-氟脲嘧啶(5-FU)、甲酰四氢叶酸钙(LV)和羟基喜树碱(HCPT)联合治疗30例进展性结直肠癌患者,结果发现完全缓解(CR)占3.3％.部分缓解(PR)为40％,总有效率43.3％,稳定者占36.7％。30例患者中位存活期为13.2月,其中,CR者为18.8月,PR者为16.5月,稳定者为11.4月。毒副反应主要有胃肠道反应和白细胞减少,但患者均能耐受。与国外学者报道相比其结果优于后者。

Background/Aims and Methods: 34 patients with advanced colorectal cancer had been treated with 5-fluorouracil, leucovorin and 10-hydroxyl camptothecinum. Results and conclusions: Thirty of 34 patients entrolled were assessable for response rate. One of them (3.3%) had complete remission (CR) and 12 patients (40%) partial remission (PR) with an overall response rate of 43.3%. In addition, 11 patients (36.7%) were stabilized. Median survival time was 13.2 months for 30 patients, 18.8 months for the patients with CR, 16.5 months for 12 patients with PR and 11.4 months for the stabilized patients. Major toxicities were found in gastrointestinal tract and hematopoietic system.