摘要
Through analysis of EST database, a 1,226bp cDNA assembled from 8 ESTs with significant similarity to human spinocerebellar ataxia2 gene(ataxin2) is found. Based on these sequences, a 4,657bp complete coding cDNA which is predicated to encode 1,052 amino acids is cloned, which is termed ataxin 2 like. Northern blot analysis indicates that human ataxin2 like has two splicing forms. Comparison analysis between human ataxin2 and ataxin2 like shows that both cDNA and the protein predicated share striking similarity. Structure analysis of the protein indicates that it is a strongly hydrophilic protein. The gene is further mapped to chromosome 9p 11 by fluoresence in situ hybridization.
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