单方左炔诺孕酮与小剂量米非司酮用于紧急避孕的临床现象

A Clinical Comparetive Study between Lower Dose Mifepristone and Levonorgestrel for Emergency Contraception

对100例身体健康、月经规律、未采取避孕措施或避免失败的妇女,在72小时内按随机方法口服米非司酮(Ru486)10mg,12小时服安慰剂一片;或服左炔诺孕酮0.75mg,12小时重复服用0.75mg。观察此两种紧急避孕方法的临床效果、副反应及对月经的影响情况。Ru486组与左炔诺孕酮组的有效率分别为100％、77.48％(按Dixon方法计算)。两组受试者中各有1例出现恶心反应,分别有2例、1例月经期延长到40余天方行经。表明低剂量Ru486与左炔诺孕酮用于紧急避孕均是安全有效的。

100 cases health women were administered with lower dose mifepristone (10mg)taken or levonorgestrel(0.75mg taken in two equal doses 12 hours apart)for emergency contraception after unprotected intercourse with in 72 hours. The efficacy were 100% and 77.48％ respectively. (Calculation with Dixon methed). The influnce in menstruation were light. There were no vomiting etc. complication occurrence. The result demonstrated lower dose mifepriston and levonorgestrel for emergency contraception were effecacy and safety.