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Expression of heavy-chain variable domain of mAb against Encephalitis Type B virus in transgenic tobacco 被引量:2

Expression of heavy-chain variable domain of mAb against Encephalitis Type B virus in transgenic tobacco
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摘要 SINCE the first report on immunoglobulin gene expression in plant by Hiatt et al. in 1989,analogous researches have been further developed. Up to now, it has become a new method touse transgenic plants and plant cells to produce antibodies and study disease-resistance breedingof crops, plant metabolism and growth, which is an organic combination of immunologyand plant sciences at molecular level. According to recent reports, both higher and lowerplants, such as tobacco, Arabidopsis, calli of maize and unicellular green alga, can
出处 《Chinese Science Bulletin》 SCIE EI CAS 1997年第12期1038-1041,共4页
关键词 immunoglobulin HEAVY-CHAIN VARIABLE DOMAIN gene EXPRESSION tobacco. immunoglobulin heavy-chain variable domain gene expression tobacco
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  • 1周晓红,陈晓光,卢丽琴,李林,吴优,咸鹏,言慧,吴琨.弓形虫SAG1基因截短片段植物表达载体的构建[J].中国人兽共患病杂志,2004,20(8):662-665. 被引量:7
  • 2王启帆,王璐,刘弟书,丁玉春.转基因植物疫苗研究进展[J].畜禽业,2007,18(9):4-6. 被引量:6
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  • 4Hiatt A,Cafferkey R,Bowdish K.Production of antibodies in transgenic plants. Nature . 1989
  • 5Hiatt A.Antibodies produced in plants. Nature . 1990
  • 6De Neve M,De Loose M,Jacobs A,et al.Assembly of an antibody and its derived antibody fragment in Nicotiana and Arabidopsis. Transgenic Research . 1993
  • 7During K,Hippe S,Kreuzaler F,et al.Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum. Plant Molecular Biology . 1990
  • 8Ma J K,Lehner T,Stabila P,et al.Assembly of monoclonal antibodies with IgG and IgA heavy chain domains in transgenic tobacco plants. European Journal of Immunology . 1994
  • 9Chaudhary V K,Queen C,Junghans R P,et al.A recombinant immunotoxin consisting of two antibody variable domains fused to pseudomonas exotoxin. Nature . 1989
  • 10McCafferty J,Griffiths AD,Winter G,et al.Phage antibodies: filamentous phage displaying antibody variable domains. Nature . 1990

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