低分子肝素治疗急性心肌梗塞后无症状性心肌缺血的初步观察

Low Molecular Weight Heparin in The Treatment of Silent Ischemia in Patients with Acute Myocatdial Infarction

目的：观察低分子肝素对急性心肌梗塞（AMI）后无症状性心肌缺血的影响。方法：随机将64例患者分为肝素1组、肝素2组和对照组共3组，均按AMI常规治疗，其中肝素1组加用皮下注射低分子肝素每日1次，每次0.4ml，肝素2组皮下注射低分子肝素每日2次，每次0.4ml，疗程2周，2周后行24小时动态心电图检查，计算总缺血和缺血总负荷。结果：各组缺血持续时间和缺血总负荷分析为：肝素1组3．4±6．8min；5.2±10.4min·mm；肝素2组2．7±7．2min，4．5±11．2min·mm；对照组9．3±10．8min;15.9±18．2min·mm.肝素1组、肝素2组与对照组比较P值均＜0．05。结论：低分子肝素能有效地治疗AMI后无症状性心肌缺血。

We studied the effects of low moleculan weight heparin on silent myocardial ischemia in patients with acute myocaridal infarction(AMI). Methods. 64. Patients with AMI were randomizdly divided into three groups (controlled 1, 2 and placebo) 24 hours of holter monitoring werenieased in all patients. Results. In Controlled group 1,total duration of silent ischemin was 3. 4±6.8min, Total ischemic burden was 5. 2 ±10. 4min mm The Controlled group 2 was 2.7±7 .2min and 4. 5 ±11. 2min. mm. The plaeebo group was 9. 3 ±10. 8 min and 15. 9 ±18. 2 min.mm. The differ ences between Controlled groups and placebo group were significant (P＜0.05 ). Conclusion. low molecular Weight heparin signicantly signicantly reduced the duation and total ischemic burden of silent ishemia in patients with AMI.