血浆纤维蛋白原与颈动脉及冠状动脉粥样硬化病变的关系

Relationship between Plasma Fibrinogen and Carotid or Coronary Artery Atherosclerosis

前瞻性随机调查103例因心绞痛、不明原因胸痛或心肌梗塞而人院行冠脉造影的患者，根据冠脉造影结果分为冠脉正常组、单支病变组及多支病变组。用标准Judkins法作选择性冠脉造影，Gensini法计算冠脉造影积分；用Acuson－128型彩色电脑声像仪作颈动脉超声，Crouse法计算颈动脉斑块积分；清晨空腹采血测定血浆纤维蛋白原(Fg)浓度；探讨Fg与颈动脉、冠状动脉粥样硬化病变的关系。结果显示，不同冠脉病变组之间Fg水平有显著差异，Fg浓度与颈动脉斑块积分。冠脉病变支数及冠脉造影积分均呈显著正相关，提示Fg水平升高在冠心病及脑卒中的发生、发展中起重要作用。

Plasma fibrinogen, carotid ultrasound and coronaxy angiography were examined in 103 patients who were divededinto normal group,1-vessel disease group and multi -ves-sel disease group according to their coronary angiographic re-sults. To quantify the exed of ed atherosis, themaximal thickness of all carotid plaques were summed for anindividual plaque score. Gensini's coronary artery diseasescore was calculated to quantify the extet of coronaryatherosclerosis. The edationship between plasma fibriogenand carotid or coronary atherosclerosis was evaluated. Theresults show tha the plasma fibrinogen was significantly higher in coronary disease group than that of normal group,and a positive relationship was forund between plasma fibrinogen and carotid plaque score or coronary atherosclerosisscore. It is concluded that high level plasma fibrinogen is significantly associated with coronary disease andstroke.