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Retroviral mediated human β-globin gene transfer and expression in vitro

Retroviral mediated human β-globin gene transfer and expression in vitro
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摘要 Retroviral mediated gene transfer of humanglobin gene into hematopoietic stem cells is apromising approach for thalassemia gene therapy.Major problem of the transferred globin gene was lowlevel expression of the gene with its proximal cis-acting sequence. The locus control region (LCR) ofthe human β-globin gene cluster consists of four majorDNase I hypersensitive sites (HS). When linked
出处 《中国实验血液学杂志》 CAS CSCD 1997年第3期286-286,共1页 Journal of Experimental Hematology
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