Adhesion and cytotoxicity susceptibility of B16 melanoma cells to immune effector cells enhanced after IL-2, IL-4 or IL-6 gene-transfection

The elimination of the tumor is closely relatedwith the sensitivity of tumor cells to the cytotoxicityof immune effector cells. We supposed that cytokinegenetransfection may increase the cytotoxicitysusceptibility of tumor cells to effector cells, and as aconsequence, the tumorigenicity decreased. Beforekilling tumor cells, effector cells required first torecognize non-specific surface adhesion molecules