Human interleukin-2 gene transfer into ovarian cancer cell lines SKOV3, decreased the proliferation, tumorigenesis and enhanced the immunity of the tumor cells
Human interleukin-2 gene transfer into ovarian cancer cell lines SKOV3, decreased the proliferation, tumorigenesis and enhanced the immunity of the tumor cells
摘要
To study the effects of human interleukin-2 genetransfer on the morphology, proliferation, tumori-genesis, immunity, and oncogenes expression of tumorcells, the gene encoding human interleukin-2 (IL-2) wasintroduced via retroviral vectors pLXSN into ovariancancer cell lines SKOV3. A resistant clone with high IL-2activity (318 U/10~6cell/24 hours) in the culturesupernatants was cloned. The hIL-2 mRNA was detectedwith RT-PCR in SKOV3/IL2 cells. The IL2 secretinghas persisted for 23 weeks with 38 passanges. The
出处
《中国实验血液学杂志》
CAS
CSCD
1997年第3期308-308,共1页
Journal of Experimental Hematology
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1李晓艳,董卫红,王泽华.Expression of Cyclooxygenase-2 in Ovarian Cancer Cell Lines[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2005,25(5):536-537.
-
2刘红菊,辛建保,陶晓南,尚丹,周琼.Immunity of Unloaded Dendritic Cells in Lung Melanoma of Mice[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2007,27(4):381-384.
-
3GAO Jian-hua,HE Zhi-juan,WANG Qi,LI Xin,LI Yi-xuan,LIU Min,ZHENG Jian-hua,TANG Hua.Low expression of SLOOP associated with paclitaxel resistance in ovarian cancer cell line[J].Chinese Medical Journal,2008(16):1563-1568. 被引量：2
-
4陈旭峰,郑树,高永良,戴惠芳,牟瀚舟,杨骅.Growth regulation of ovarian cancer cell line HO-8910 by transforming growth factor β1 in vitro[J].Chinese Medical Journal,1998(6):66-70. 被引量：1
-
5NEOPLASMS[J].China Medical Abstracts(Internal Medicine),1997,14(1):12-14.
-
6连新云,张连峰,蔡有余.受体介导的基因转移系统[J].中国实验动物学杂志,1996,6(3):179-181.
-
7HU Jin Yue, WANG Sa, ZHU Jian Gao, ZHOU Guo Hua and SUN Qu Bing.Expression of B7 costimulation molecules by colorectal cancer cells reduces tumorigenicity and induces anti-tumor immunity[J].World Journal of Gastroenterology,1999,5(2):59-63. 被引量：20
-
8Rui BAI,Zhong SHI,Jia-wei ZHANG,Dan LI,Yong-liang ZHU,Shu ZHENG.ST13,a proliferation regulator,inhibits growth and migration of colorectal cancer cell lines[J].Journal of Zhejiang University-Science B(Biomedicine & Biotechnology),2012,13(11):884-893. 被引量：1
-
9维生素D为何能对抗结肠癌[J].岭南现代临床外科,2015,15(2):197-197.
-
10浦佩玉,徐小华.STUDY ON THE MECHANISM OF ESCAPING IMMUNE SURVEILLANCE IN HUMAN GLIOMAS[J].Chinese Journal of Cancer Research,1998,10(4):43-48.
