盐酸戊乙奎宁对敌敌畏致脑电改变的对抗作用

EFFECTS OF PENEQUININE HYDROCHLORIDE ON EEG CHANGES INDUCED BY DICHLORVOS IN RATS

敌敌畏15mg·kg^(-1),可致大鼠脑电出现去同步化,少数出现癫痫波,大部分动物死亡。剂量增大至20mg·kg^(-1),癫痫波的发生数未见增加,表明敌敌畏引起的改变以去同步化为主。预防给药中盐酸戊 乙奎宁2mg·kg^(-1),可完全对抗敌敌畏所致的脑电图变化;ip阿托品2mg·kg^(-1),仅部分对抗。当剂量增大至4mg·kg^(-1)时,虽然动物存活数略有增加,但去同步化及癫痫波的发生数也增加。提示盐酸戊乙奎宁对敌敌畏中枢毒性有较好的对抗作用。

Dichlorvos (DDVP) 15mg · kg^(-1), ip, produced desynchronization activity in EEG in all rats and epileptiform activity only in a few animals, most of them died. Pretreated with Penequinine Hydrochloride (PCHE) 2mg·kg^(-1), ip, the above EEG changes could be fully antagonized.Atropine (Atr) only antagonized EEG changes in part of animals. When the dose was increased to 4mg· kg ^(-1), the number of rats developed epileptiform was even increased. The results indicated that the characteristic of EEG following DDVP poisoning is desynchronized activity, which is antagonzed completely by PCHE and partly by Atr.