摘要
本文试验水芹、龙胆、旋复花、人黄、黄芪5种中药粗提物对鸭乙型肝炎病毒逆转酶(DHBV-RT)和DNA聚合酶(DHBV-DNAP)的抑制作用。结果表明,药物对DHBV-RT和DHBV-DNAP的抑制特性类似。5种中药粗提物对上述两种酶都有不同程度的抑制作用,按强弱顺序依次为水芹、旋复花、龙胆、大黄和黄芪。阳性对照药-膦羧基甲酸钠(PFA)对DHBV-RT和DHBV-DNAP的抑制作用均较强。提示,水芹等5种中药可能有抗乙肝病毒作用。
We have tested the effects of extracts of five Chinese traditional medicines on duck Hepatitis B viruses reverse transcriptase (DHBV-RT) and DNA polymerase (DNAP). The re-sults showed that Oenanthe javanica, Inula britannica, Gentiana scabra, Rheum palmatum inhibited DHBV-RT and DNAP significantly. Their IC50 were 407、 549、 633、 884ug/ml on DNAP and 542、 560、698、747ug/ml on RT respectively. The inhibition of Astragallus membtranaceus on those enzymes was lower. The results suggested that RT and DNAP may be the target enzymes of antihepatitis B viruses of the five Chinese medicines, which are very hopeful of being antihepatitis B viruses agents, (drugs)
出处
《解放军药学学报》
CAS
1997年第2期71-73,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
国家新药基金资助课题(编号:1995-011)
