慢性肾功能衰竭血液透析病人血浆水溶性脂质过氧化物的改变及意义

The Change Significance of WSFS in CRF Patient's with Hemodialysis

自由基与各种肾病及其终未期的发生和发展有密切关系。本文对31例尿毒症患者的血浆水溶性脂质过氧化物（WaterSolubleFlurescentSubstancer．WSFS）用荧光光谱法进行测定，并与正常人及尿毒症病人血液透析前后的WSFS变化对比分析，结果显示尿毒症病人的WSFS明显升高，提示WSFS检测可以从一个侧面了解患者体内氧化应激增强状态及对病人的肾功能和心脑血管并发症发展趋势的判断具有一定意义。此外由于血液透析不能明显降低患者血浆WSFS含量，提示对尿毒症病人进行血液透析改善内环境同时，还应积极给予抗氧化物及抗氧化物酶的治疗具有重要意义。

The water soluble fluorescent substances 9WSFS) value in plasma of 31 cases of chronic renalfailure (CRF) was determined, before and after the patient's blood had been dialysed before andafter the dialysis, the WSFS level by 5 - fold compared to the level in the control persons, Therewas no signific and difference of WSFS between undialysed CRF plasma and dialysed CRF plasma.These results indicated the free radical in CRF patients was increased and it enhanced lipidperoxidation. Because WSFS were m binding compounds between the degraded lipids and serumproteins, They were big molecules, so could not be cleared away easily by blood dialysis.