鼠胃癌及癌前病变时外周血、胃粘膜和胃液的维生素改变及其机理探讨

Changes of Vitamin Levels in Blood, Gastric Mucosa and Juice in Rats with Gastric Cancer and Precancerous Lesions and Its Mechanisms

目的:建立大鼠胃癌模型,研究抗氧化维生素在胃癌发生中的作用。方法:通过微量生化法,我们观察胃癌及癌前病变阶段外周血、胃粘膜组织和胃液中抗氧化维生素浓度的改变。结果:胃癌及癌前病变阶段,组织中β-C、维生素C及胃液的维生素C较其对照组降低,后者最显著,其机理可能与限制自由基介导的损伤、清除亚硝酸盐及减少内源性亚硝基化合物的形成有关。结论:研究提示抗氧化维生素与胃癌发生的关系可追溯到癌前病变阶段,胃液及粘膜浓度改变比血中的变化更有意义。

Aims: To investigate the roles of anti-oxidant vitamins in gastric cancer. Methods: An experimental model of rats with gastric cancer and precancerous lesion was established and anti-oxidant vitamins levels in the blood, gastric mucosal tissue and gastric juice were analysed. Results: Concentrations of β-C and vitamin C in gastric tissue and vitamin C in gastric juice were lower than in control groups. The mechanisms may associate with the roles of anti-oxidant vitamins in the reduction of tissue damage caused by free radical, by scavenging nitrite and decreasing the endogenous formation of N-nitroso compounds. Conclusions: There was correlation between anti-oxidant vitamins and gastric cancer and precancerous lesion. The changes of anti-oxidant vitamins were unremarkable in blood samples.