^(13)C-尿素呼气试验诊断幽门螺杆菌感染的研究

Reliability of ^(13)C-Urea Breath Test (UBT) in Detection of Helicobacter pylori Infection

本研究旨在评估^(13)C,尿素呼气试验检测幽门螺杆菌感染的可靠性。方法:我们在82例因胃病而行胃镜检查的患者胃窦和胃体取多个活检标本,作组织学、牯膜涂片和快速尿素酶试验,以决定是否感染幽门螺杆菌,并作^(13)C-尿素呼气试验。^(13)C-尿素呼气试验的敏感性、特异性、阳性预测值、阴性预测值是与组织学和尿素酶方法检测幽门螺杆菌的结果比较而计算得到。结果:^(13)C-尿素呼气试验的敏感性97.92％,特异性100％,阳性预测值100％,阴性预测值97.14％,准确性98.78％。结论:^(13)C-尿素呼气试验有高度敏感性和特异性,对确定患者的幽门螺杆菌感染状态是一可靠的无创伤的诊断方法。

To assess the reliability of UBT in detection of H. pylori in fection. Methods:82 patients were endoscopied and their status of H. pylori was determined by histologic examination and rapid urease test (RUT), as well as 13C-UBT. Comparing with the histologic examination and RUT, sensitibility, specificity, positive predictive value (PPV), negative predictive value (NPV) of UBT were calculated. Results: The sensilibity, spcificity, PPV and NPV were 97.98%, 100%, 100% and 97.14% respectively. Conclusion: Non-invasive 13C-UBT is highly sensitive and spectific, and could be as a 'gold standard' for detection of H. pylori infection.