幽门螺杆菌对十二指肠球部溃疡患者生长抑素的影响

The Effect of Helicobacter Pylori on Somatostatin Level in Serum and Gastric Mucosa in Patients with Duodenal Ulcer

应用放免法测定23例十二指肠球部溃疡(其中17例Hp阳性,6例Hp阴性)患者血浆及胃窦组织生长抑素含量(SS),9例Hp阴性的浅表性胃炎为对照组。结果:3组血浆SS含量无明显差异(P>0.05);十二指肠球部溃疡Hp阳性组和Hp阴性组胃窦组织SS分别为7.05±1.67pg/mg湿重和8.35±3.2pg/mg湿重,与对照组(14.55±1.8pg/mg湿重)相比有显著性差异(P<0.002,P<0.05),但Hp阳性组十二指肠球部溃疡与Hp阴性组相比无明显差异。结论:胃窦生长抑素降低与十二指肠球部溃疡胃酸分泌异常有关,而Hp似与之无关联。

Background/Aims: To evaluate the influence of Helicobacter pylori (Hp) on serum and gastric mucosal somatostatin levels in patients with Hp associated duodenal ulcer. Methods: Serum and gastric antral mucosal somatostatin levels were measured by radioimmunoassay (RIA) in 9 patients with Hp negative chronic superficial gastritis served as controls and 23 patients with duodenal ulcer (17 Hp positive and 6 Hp negative). Results: There was no difference in serum somatostatin levels among the controls, the patients with Hp positive duodenal ulcer and Hp negative duodenal ulcer (9.62 ±1.9pg/ml, 13.62±2.22pg/ml and 9.55±2.91pg/ml, respectively, P>0.05). With regard to antral mucosal somatostatin level, it was significantly decreased in patients with Hp positive duodenal ulcer and Hp negative duodenal ulcer as compared to the controls (7.05±1.67pg/mg, 8.53±3.2pg/mg, and 14.55±1.8pg/mg, respectively, P< 0.002, <0.05), no difference was found between Hp positive and Hp negative duodenal ulcer. Conclusions: The decreased somatostatin level in gastric antral mucosa in patients with duodenal ulcer might be related to abnormality of gastric acid secretion, it seems unlikely to be related to Hp infection.