摘要
本文报道肝细胞生长因子(HGF)、丹参和两药联用对CCl_4所致大鼠肝损伤有保护作用,表现为血清ALT、α-肿瘤坏死因子(TNF-α)、丙二醛(MDA)、肝组织匀浆MDA、肝组织钙含量和血清及肝匀浆超氧化物歧化酶(SOD)活力及光镜、电镜下肝组织病变均有明显改善,且联用优于单用。本文还对HGF、丹参合用所起协同作用的机理作一简短的讨论。
Background/Aims: To investigate the protective effects of hepatic growth factor (HGF) and Salvia Miltiorrhiza (SM) on acute liver injury induced by CC1< in rats. Methods: Acute liver injury of rats was induced by CCL administered introperitoneally. Animals were divided into 5 groups: CCL, HGF, SM, HGF+SM and normal groups. After given above drugs at different time, serum ALT and TNF-α were measured, the liver specimen was observed histologically and the levels of MDA, SOD, Ca++ in liver tissue were compared among different groups. Results: the levels of ALT, TNF-α, MDA, calcium, SOD, and pathological changes of the liver were imporved obviously in HGF or SM and HGF + SM groups, The protective effects in group HGF + SM were better than that in HGF or MS groups. Conclusions: HGF and SM have a good results in protecting hepatocyte degeneration and necrosis induced by CCl4 in rats.
出处
《胃肠病学》
1997年第1期43-47,共5页
Chinese Journal of Gastroenterology
