血浆同型半胱氨酸水平对糖尿病视网膜病变的预测意义

Predicting value of plasma homocysteine concentrations for diabetic retinopathy

目的探讨血浆同型半胱氨酸与糖尿病视网膜病变（DR）的关系。方法比较40例DR（DR组）和63例非DR（非DR组）2型糖尿病患者血浆同型半胱氨酸水平、病程、年龄、血压、空腹血糖、糖化血红蛋白（GHbA1c）、血脂、叶酸及维生素B12等与DR可能相关的指标。结果DR组血浆同型半胱氨酸水平中位数为12．9μmol／L，与非DR组的7．8μmol／L比较，差异有统计学意义（P〈0．01），两组在校正了病程、GHbA1c、年龄、叶酸及维生素B12后仍显著相关（OR值1．23，P〈0．05）。结论高同型半胱氨酸血症为DR的危险因素，并为独立的预测因子。

Objective To explore the relationship between plasma homocysteine levels and diabetic refinopathy （DR）. Method In 40 DR patients and 63 non-DR patients, the indexes including plasma homocysteine concentrations, duration of diabetes, ages, blood pressure, preprandial blood glucose（PBG）, plasma GHbA1c, plasma lipids, serum folic acid and serum vitamin B12 were analyzed. Results Plasma homocysteine level was significantly higher in DR patients （12.9 μmol/L） than that in non-DR patients （7.8 μmol/L） （ P 〈 0.01 ）, and the relationship remained significant correlation after adjusted for duration of diabetes, GHbA1c, ages, serum folic acid and serum vitamin B12（OR = 1.23, P〈0.05）. Conclusion Hyperhomocysteinimia is a risk factor and an independent predicator of DR.