腹腔镜保守性手术后应用促性腺激素释放激素激动剂联合去氧孕烯炔雌醇治疗卵巢子宫内膜异位囊肿疗效评价

Clinical effect of gonadotropin releasing hormone-analogue and marvelon in the treatment of ovarian endometriasis after laparoscopy

目的探讨卵巢子宫内膜异位囊肿行腹腔镜保守性手术后应用促性腺激素释放激素激动剂（GnRH-a）联合去氧孕烯炔雌醇（妈富隆）的治疗效果。方法选取59例卵巢子宫内膜异位囊肿患者，其中腹腔镜保守性手术后应用GnRH-a联合妈富隆治疗的患者19例（A组），行腹腔镜保守性手术后单用GnRH-a治疗的患者20例（B组），行腹腔镜保守性手术后未用药物治疗的患者20例（C组）。比较三组术后总主观症状评分、复发情况，并观察药物的不良反应。结果术后3年A组复发囊肿的直径及总主观症状评分分别为（12±1）mm和（1．2±0．9）分，在三组中均为最低（P〈0．05）。结论腹腔镜保守性手术后应用GnRH-a联合妈富隆对卵巢子宫内膜异位囊肿的疗效优于术后单用GnRH-a和术后未用药物者。

Objective To study the clinical effect of gonadotropin releasing hormone-analogue （GnRH-a） and marvelon in the treatment of ovarian endometriosis after laparoscopy. Method The post- operative women with ovarian endometriosis were divided into three groups： 19 treated with GnRH-a and marvelon（group A）, 20 treated with GnRH-a（group B）, 20 without endocrinal therapy（group C）. The symptoms scores, the recurrence and side effects were compared. Results Three years after laparoscopy, the recurrent rate and symptoms scores in group C was the highest （P 〈 0.05）, the recurrent cyst size [ （ 12 ± 1 ） mm ] and symptoms scores [ （ 1.2 ± 0.9 ）scores ] in group A was the lowest among three groups. Conclusions Marvelon and GnRH-a can be used in the treatment of ovarian endometriosis after laparoscopy. The effect of marvelon combined with GnRH-a is prior to GnRH-a.