高压氧治疗急性重度颅脑损伤后血内皮素及经颅多普勒超声的研究

The study on the alteration of endothelin(ET) and transcranal doppler(TCD) after heperbaic oxygen treatment for acute severe cranocerebral injury.

以重度颅脑损伤患者35例为治疗组,20例为对照组,观察高压氧治疗前后血内皮素、经颅多普勒超声变化,从而探讨高压氧治疗重度颅脑损伤的机制。结果治疗组血内皮素及经颅多普勒超声在高压氧治疗前明显升高异常,治疗后明显下降改善,有统计学意义;而对照组下降改善不明显。高压氧可降低重度颅脑损伤患者急性期血内皮素,改善大脑中动脉血流速度及血管阻力,从而改善脑外伤后脑血管痉挛及脑缺血缺氧。

Patients were divided into the treatment group who consist of 35 patients and the control group who consist of 20 cases,to observe the alteration of endothelin(ET), transcranal doppler (TCD) before and after hyperbraic oxygen tratment for acute severe cranocere-bral injury. In the treatment group ET reduced greatly, TCD bettered after the treatment , it reach statistical significance. Hyperbraic oxygen treatment could improve the a-cute severe cranocerebral injury patients cerebral vascular spasms and cerebral ischemia and hypoxia by decreasing acute stage ET and im-proveng the blood velocity of middle cerebral artery and cerebral vascular resistance, lowering intracranial pressure was one of importantmechanism of hyperbraic oxygen treatment foracute severe cranocerebral injury.