老年肺部感染血清肿瘤坏死因子的临床研究

A study on tumor necrosis factor in the aged pa-tients with lung infection.

测定了38例老年肺部感染患者和30例正常老年人血清肿瘤坏死因子(TNF)水平,结果显示TNF在老年肺部感染组(37.42±5.24fmol/mL),感染并心衰组(44.12±4.54 fmol/mL),均较正常对照组(16.75±1.92 fmol/mL)明显升高(P<0.01)。上述研究表明TNF在老年肺部感染,感染合并心力衰竭,合并多器官功能衰竭(MOF)的病程中起着重要的作用,而TNF升高与感染病变的严重程度,有无合并症相关,同时也是判定老年肺部感染在预后方面的重要指标。

Serum levels of tumor necrosis factor in the aged patients with lung infection in 38 cases and 30 normal controls. The results showed tumor necrosis factor in the aged with lung infection group (37. 42 ±5. 24 fmol/mL) and lung infection with heart failure group (44.12±4. 54 fmol/mL) was significantly higher than that in normal controls (16. 75 ±1. 92 fmol/mL) (P<0. 01). This study showed the tumor necrosis factor may play an important role in the aged patients with lung infection, lung infection with heart failure and lung infection with multiple organ failure in the whole course. Tumor necrosis factor increased with closely related to the development of infection and complications or not. It is an important indexes for judging the progress and prognosis in the aged patients with lung infection.