对冠心病患者血管内皮细胞纤溶活力的研究

The fibrinolytic activity of endothelial cells in patients with coronary artery disease

我们对12例心肌梗塞患者、13例心绞痛且冠状动脉造影阳性患者以及12例有易患因素但冠状动脉造影正常患者,在束臂(10分钟)前、后测定了血浆纤溶成份以及vWF:Ag水平,并与10例正常人对照。结果显示:心肌梗塞患者以及心绞痛患者基础及束臂后激发的纤溶活力均低于正常对照,其中以心肌梗塞患者纤溶受损最为严重;有高血压、高血脂、吸烟以及糖尿病等冠心病好发因素,但冠状动脉造影阴性的患者其纤溶活力也较正常低,提示这些因素会使内皮细胞功能受损,从而抑制纤溶活力。

The study was designed to evaluate the role of fibrinolytic system in coronary artery disaese. In 12 patients (group 1) with acute myocardial infarction, 13-patients (group 2) with angina and positive anginography,12 patients (group 3) with risk factors of coronary artery disease and normal anginography and 10 healthy controls,before and after venous occulsion (10minutes),fibrinolytic system (tpA activity,tpA antigen,PAI - 1 activity and D - D) and vWF antigen levels were measured. The result showed before and after occulsion the fibrinolytic activity of both group 1 and group 2 was lower than controls,group 1 was lower than group2. It also showed the fibrinolytic activity in group 3 was lower than controls. It suggested that hypertension,diabetes mellitus,smoking, hyperlipidemia might damage the endothelial cells function and fibrinolytic activity. Those patients with risk factors of coronary artery disease had inclination to thrombosis.