血栓性疾病血小板功能的综合分析

Comprehensive analyses of the platelet function of thrombotic diseases

本文以6种指标检测高血压、心绞痛、急性心肌梗塞、脑梗塞、脑出血、糖尿病等血栓性疾病的血小板及血管内皮功能,发现变化最显著或最敏感的是β-TG及血小板粘附性,其次为PF_4与TXB_2,再次为血小板聚集性与6酮-PGF_(1α)。这种规律变化有助于对上述试验的评估和选择。同时检测全血粘度及血浆粘度也都有明显变化。

Six thrombotic diseases(hypertension, agina pectoris, acute myocardial infarction,diabetes mellitus,cerebral haem-orrnage ana cerebral infarction) were investigated by platelet adhesive,platelet aggregation, Betathromboglobin(β- TG),platelet factor 4(PF4) ,thromboxane B2(TXB2), 6 - Keto- prostaglandin (6Keto- PGF1α) ,as well as whole blood and plasma viscosity detection. We discovered that these diseases had similar platelet function changes. The most prominent or the most sensitive changes were β - TG and platelet adhesive, the next were PF4 and TXB2, and then platelet aggregation and 6 - Keto - PGF1α. The regularity will help the physician to estimate the various function tests and to select the related tests according to the lab conditions available. Apart from the alteration of platelet fuction,most investigated patients showed obvious elevation in the whole blood and plasma viscosity simultaneously, which suggested that the hemorheology changes took part in the thrombotic event.